Para-interstitial emphysema of the upper lobes of both lungs is a type of emphysema, which is mainly considered to be caused by exposure to dust and respiratory infections. Most of the patients are asymptomatic, while a few of them will have symptoms such as shortness of breath and coughing, and there will be complications if they are not treated in time. 1. Para-interstitial emphysema of the upper lobes of both lungs is a type of emphysema that refers to the imaging findings that appear when a patient undergoes CT examination of the lungs. This type of emphysema is mainly confined to the interlobar fissures, pleura, and paramediastinum of the upper lobes of the two lungs, and the patient will have pulmonary blisters under the pleura. 2. The parietal emphysema of the upper lobe of both lungs may be caused by long-term exposure to occupational dust, recurrent respiratory infections, long-term smoking, etc. Most of the patients do not have obvious symptoms, and a few of them may have exertional shortness of breath, cough, and other manifestations. 3. However, if patients do not take timely measures for treatment, complications such as chronic obstructive pulmonary disease (COPD) or chronic pulmonary heart disease (CHD) may occur with the development of the disease. It is recommended that patients with paraspinal emphysema in the upper lobes of both lungs should consult a doctor in a timely manner, and can choose appropriate measures for treatment under the guidance of the doctor. Patients need to quit smoking, pay attention to keep warm, and if necessary, can improve the symptoms of hypoxia through home oxygen therapy.