Enlargement of the groin may be caused by inguinal lymphadenitis, inguinal lymphoma, and inguinal hernia. Patients can be treated with oral medication or surgery under the guidance of doctors. 1. Inguinal lymphadenitis: Inguinal lymphadenitis, which can be manifested as enlarged lymph nodes in the groin, often accompanied by pain, fever and other symptoms, is usually caused by the spread of infection from the lower limbs to the groin. It can be treated with oral azithromycin and erythromycin. 2. Inguinal lymphoma: lymphoma is a malignant tumor of blood system, in addition to enlarged lymph nodes in the groin, enlarged lymph nodes can also appear in other parts of the body, usually without pain. Patients can be treated with chemotherapy or radiotherapy after surgery in regular hospitals. 3. Inguinal hernia: Inguinal hernia is caused by the increase of abdominal pressure and the weakness of the abdominal wall, which is manifested by the appearance of a swelling in the groin, and the swelling appears when the patient increases abdominal pressure. It can be treated by tension-free hernia repair or transperitoneal hernia repair. If the patient appears inguinal swelling should go to the regular hospital in time for examination, under the guidance of a professional doctor for treatment, the use of medication, need to follow the doctor’s instructions.