When a patient with polycystic ovary syndrome is actively preparing for pregnancy 1. I am a patient with polycystic ovary syndrome and I want to consult how to get pregnant, why am I prescribed contraceptives instead? The pill is not only for contraception, but also for menstrual cycle adjustment and anti-hyperandrogenism. Although the pill does have a contraceptive effect, it is more of a treatment for patients with polycystic ovary syndrome who suffer from menstrual irregularities and hyperandrogenism. Only in the case of correcting the disorder of the internal environment, it is possible to have a good ovulation treatment effect and to create a suitable condition for the baby to be laid, otherwise, direct ovulation may fail and conception is prone to miscarriage. 2. Do patients with polycystic ovary syndrome need to regulate their menstruation regularly in order to get pregnant? Most patients with polycystic ovary syndrome need to rely on medication to maintain regular menstruation. Once the medication is stopped, the patient will soon have irregular periods due to the lack of ovulation. It is usually a waste of time and a misconception to keep waiting to regulate your periods before getting pregnant. Patients with polycystic ovary syndrome who are ready to get pregnant can use ovulation-promoting drugs to promote ovulation and pregnancy after a period of treatment to adjust their own endocrine and metabolic conditions, such as effective weight loss, decreased insulin glucose levels, and improved lipid biochemical inflammatory indicators. 3.How long do I have to take the medication to get pregnant with polycystic ovary syndrome? Can I get pregnant immediately after stopping the medication? Will it have any adverse effect on the baby? Patients with polycystic ovary syndrome are not easy to get pregnant because their ovulation is not normal, most of the time is anovulation, high androgen, insulin resistance, abnormal glucose tolerance and other metabolic disorders are not suitable for embryo implantation, even if the embryo implantation is successful, the incidence of miscarriage is higher than normal. Therefore, it depends on whether the endocrine and metabolic disorders have been corrected, and it needs to be confirmed after review, and the length of medication is not consistent for each person. If it is a short-acting estrogen and progestin, it can promote ovulation after menstruation and will not affect conception or have adverse effects on the baby, while more other drugs require individualized assessment by clinicians. 4.I have not been pregnant for more than a year after marriage. My doctor said I have polycystic ovary syndrome, why does it affect pregnancy? Can I still get pregnant naturally? Normal women of childbearing age have one follicle that matures and ovulates every month. In polycystic ovary syndrome, there is hyperandrogenism and hyperinsulinemia, and the hormonal and metabolic abnormalities lead to the accumulation of dozens and dozens of small follicles in the ovaries, which do not mature and prevent ovulation, thus making the patient infertile. However, patients with polycystic ovary syndrome are not absolutely infertile. The chance of natural conception is related to the severity of insulin resistance, obesity and other symptoms, and some obese polycystic patients may experience natural ovulation and conception after weight loss or metformin and other medication. 5. Some patients with polycystic ovary syndrome have difficulty conceiving naturally, what should they do? For patients with polycystic ovary syndrome combined with infertility, it is recommended to check the husband for semen abnormalities and the woman for tubal obstruction. After the above causes of infertility are ruled out, the preferred treatment for the woman is to take oral ovulation-promoting drugs to induce ovulation. If polycystic ovary syndrome is combined with hyperinsulinemia, the addition of metformin increases the sensitivity of ovulation promotion. In patients with hyperandrogenism and LH, adjustment with oral short-acting contraceptives is required before ovulation promotion. In some patients who are resistant to clomiphene and still do not ovulate after the drug, gonadotropin injections can be given, and nearly half of the patients can get pregnant after six months to a year of the drug. However, the chances of ovarian hyperstimulation syndrome are higher when this drug is used. Those who do not do well with ovulatory drugs need to be considered by the attending physician at his discretion to analyze the cause and whether further adjustments should be made to the treatment of hyperandrogenemia and metabolic abnormalities; laparoscopic ovarian perforation is the second-line treatment option, which uses electric needles to destroy some ovarian tissue, thus reducing androgens and normalizing ovarian function, with the prospect of a short-term return to ovulation after surgery. However, it needs to be chosen carefully because it is an invasive tool plus the efficacy does not last long. If the drugs and surgery have failed or the surgery is not accepted, then we cannot delay any longer and can consider assisted reproduction techniques to help conception, such as doing in vitro fertilization-embryo transfer. 6.I am a patient with polycystic ovary syndrome and I have had several intermittent ovulation promotions in the past 2 years, but why can’t I conceive with intercourse? The causes of infertility are complex. For polycystic ovary syndrome, ovulation disorder is the most common cause, however, other factors can’t be excluded. However, other factors cannot be ruled out, such as blocked fallopian tubes, immune factors, fertilization disorders, embryo implantation disorders, and poor quality of male semen. Therefore, if other factors of infertility are combined, it is possible that conception may not be successful even if there are dominant follicles with multiple ovulation inductions. In this case, it is recommended to re-evaluate the cause of infertility in order to solve the problem with the right medicine. In addition, the wrong timing of intercourse can also lead to difficulties in conceiving. It is necessary to have intercourse at the right time and live an effective life under the guidance of a doctor. Effective intercourse is when couples have intercourse one or two days before and on the day of ovulation, when they are most likely to get pregnant. During this time, the timing of intercourse can be adjusted according to ultrasound monitoring and hormone levels. If you have intercourse after this effective time, it is not helpful for pregnancy.