Treatment for gout includes anti-inflammatory analgesics and uric acid-lowering drugs. Anti-inflammatory analgesics may have a certain effect on kidney function, and uric acid-lowering drugs have very little effect. But theoretically, there is no such thing as a drug that absolutely does not hurt the kidneys. 1. Anti-inflammatory analgesics include: (1) Non-steroidal anti-inflammatory drugs such as etoricoxib, celecoxib, diclofenac sodium, ibuprofen all belong to this class of drugs. Long-term use of NSAIDs can cause some damage to the kidneys. (2) Colchicine: It has anti-inflammatory effect and can inhibit the release of inflammatory factors to achieve pain control. Chronic renal insufficiency will reduce the excretion of colchicine and increase the toxicity of the drug, colchicine is prohibited in patients with hepatic and renal insufficiency. (3) Glucocorticoids: basically will not cause damage to the kidneys, the drugs include prednisone, etc. For patients with high uric acid accompanied by severe renal insufficiency, hormones can be used for treatment. As the long-term use of hormones can lead to sodium retention, infection, osteoporosis, hypertension, hyperlipidemia, etc., the use of time should not be too long. 2. Uric acid-lowering drugs include drugs that reduce uric acid production and drugs that promote uric acid excretion. (1) Reduce the formation of uric acid commonly used drugs are allopurinol and febuxostat. Febuxostat has a strong uric acid-lowering effect and is usually preferred for patients with high uric acid combined with renal insufficiency. (3) Drugs that promote uric acid excretion include benzbromarone, which can inhibit the reabsorption of uric acid in renal tubules and promote uric acid excretion. Patients with gout may have different degrees of renal impairment and need to assess renal function based on glomerular filtration rate and choose the appropriate drug under the guidance of a doctor.