Cryptococcus infection of the lungs to take fluconazole, the general use of medication time for 1-6 months, or even longer, specific need to be based on the patient’s condition and physical fitness to decide. Cryptococcus is a type of fungus, which can be transmitted through droplet transmission and aerosol inhalation, and mostly occurs in people with low immunity of the body. After cryptococcal infection of the lungs, the main use of antifungal drugs for treatment, the specific treatment how long, and the patient’s immune status, the severity of the disease is related. For patients with milder symptoms of cryptococcal lung infection and normal immunity, oral fluconazole treatment for 1-2 months will result in significant improvement or even cure for most patients. For more serious symptoms, immunocompromised patients, such as AIDS patients, patients taking immunosuppressants for a long time, taking fluconazole treatment cycle is longer, at least 6 months or even 1-2 years. In some patients, the treatment is not effective after the emergence of drug resistance, at this time, it is recommended to switch to amphotericin B for treatment. For those with cryptococcal lung infections, it is necessary to determine when the drug can be discontinued based on the results of cryptococcal cultures, serum podopanel polysaccharide antigen tests, and lung CT results. During long-term use of fluconazole, make sure to perform follow-up liver and kidney function tests to avoid toxicity of the drug to the liver and kidneys. It is contraindicated in people who are allergic to fluconazole, pregnant women and breastfeeding women. In the event of a cryptococcal infection of the lungs, it is important to seek medical attention, strictly follow medical advice for treatment, and follow the doctor’s instructions for regular follow-up.