The role of taking Orlistat is that it can help overweight people to reduce weight, in the use of the drug need to pay attention to abdominal discomfort and other adverse reactions, contraindications and so on. Orlistat can inhibit gastrointestinal lipase activity, so that the gastrointestinal fat can not be absorbed by the body, thus reducing calorie intake, weight control. The drug can be used for weight-lowering therapy in obese and overweight people with concomitant risk factors. In its use it is recommended to combine it with a slightly low-calorie diet. Adverse reactions such as vitamin malabsorption, fecal urgency or incontinence, steatorrhea, respiratory infections, headaches, menstrual disorders may occur with the use of this drug. It is contraindicated in people who are allergic to this drug; people under 18 years of age; pregnant and breastfeeding women; people with organic obesity due to chronic malabsorption syndrome, cholestasis, hypothyroidism, etc.; people with a history of previous organ transplantation; people who are using drugs such as cyclosporine; and people with a height and body mass index of less than 24. Orlistat needs to be used under the guidance of a clinician, unauthorized use of drugs is prohibited; overweight, it is recommended that the combination of exercise and dietary control at the same time.