Stubborn acne requires standardized medication, physical therapy, and general measures to improve the symptoms of the disease. 1. Standardized medication: Stubborn acne may be caused by the patient’s failure to take standardized medication, or the poor efficacy of medication. Therefore, patients need to take into account their own situation and strictly follow the doctor’s instructions for the use of drugs. Clinically, patients can use topical retinoic acid drugs, such as retinoic acid cream, adapalene gel, or oral isotretinoin soft capsules. Some patients can also take oral antibiotics, such as minocycline, tetracycline and so on. 2. Physical therapy: during the medication, patients can also take physical therapy, such as photodynamic therapy, laser therapy, etc., which can destroy Propionibacterium acnes through photodynamic effect, thus reducing inflammatory reaction and improving prognosis. 3. General treatment: During the treatment period, patients should avoid scratching the lesion area, keep the local skin clean and clean, and properly control oil cleansing. Maintain a regular life, ensure sufficient rest time, do not stay up late for a long period of time, and at the same time, manage their own bad emotions and stress. Patients with persistent acne are advised to standardize their medication under the guidance of a doctor, and to follow the doctor’s instructions for regular review during the treatment period, so as to understand the recovery of the disease.