Soreness in the muscles of the anterior thigh may be due to muscle strain, nerve inflammation, nerve entrapment and so on. 1. Muscle strain: Soreness on the front side of the thigh is usually due to strain or injury of the quadriceps muscle on the front side of the thigh, such as running and other strenuous exercise, which may lead to the muscle is in a strong state of stretching, or lactic acid buildup, which leads to severe soreness on the front side of the thigh. 2. Nerve inflammation: when the femoral nerve is stimulated by cold or squeezed and other conditions resulting in aseptic inflammation, it may lead to edema of the femoral nerve in the inguinal outlet, which causes soreness and numbness of the muscles in the anterior group of the thigh, and other symptoms. 3. Nerve entrapment: When patients with lumbar disc herniation or femoral nerve or lateral femoral cutaneous nerve entrapment, it may produce radiating pain and lead to soreness of the anterior thigh muscles. There are many reasons for the soreness of the anterior thigh muscles, and you should consult a doctor in time to make a clear diagnosis and then do the next step of treatment.