Hepatitis C Virus Markers Hepatitis C Virus Antibody Test: The body produces antibodies to the hepatitis C virus as soon as it becomes infected with it. A positive test for anti-HCV means that the person is or has been infected. However, there are 40-50% of false positives in normal people. Therefore, additional testing for HCV RT-PCR or RIBA is required for suspected false positives. Hepatitis C virus RNA, a positive test indicates the presence of hepatitis C virus replication. It is an indicator to confirm the presence of hepatitis C virus infection and to evaluate the effectiveness of antiviral therapy.