With the continuous development and innovation of medicine, the success rate of surgical treatment of epilepsy has improved greatly, and many people are willing to treat epilepsy with surgery, but it is worth noting that not all epilepsy patients can be treated with surgery, and it has certain indications. So what are the contraindications to surgery for epilepsy? 1, with severe diabetes, cardiovascular system disease and other serious medical diseases (increasing surgical disability or mortality); 2, with IQ below 70 or who cannot cooperate with extracorporeal stimulation after surgery; 3, with progressive medical or neurological disease; 4, with local skin infection on the head or subclavian; 5, with imaging findings of occupying lesions or with progressive neurological disease, for surgery unable to cooperate, or have severe behavioral disturbances that affect postoperative health; 6. Memory dysfunction in the hemisphere contralateral to the lesion; 7. Active psychosis with severe character and personality disorders; 8. Primary generalized epilepsy; 9. Minor seizures that do not affect life; 10. Patients who are young, whose brains are not yet mature, whose seizure tendencies are not obvious, whose seizure types are not yet defined, or who are elderly, whose brains who have already shown significant degenerative lesions and are estimated to have poor surgical outcome. The selection of patients for epilepsy surgery should conform to the following basic principles: they must be drug-refractory epilepsy, and there must be a clear epileptogenic focus; surgery must not cause severe functional impairment; for patients with structural brain lesions, it is not necessary to meet the criteria for refractory epilepsy, and those who can be operated should be operated as early as possible; for young children, in principle, early surgery should be performed to interrupt the seizure on brain development and function as early as possible The negative effects of seizures on brain development and function should be interrupted as early as possible.