1.Menorrhagia resulting in secondary anemia and ineffective drug treatment. 2.Severe abdominal pain, painful intercourse or chronic abdominal pain, acute abdominal pain caused by twisting of O myoma; 3.Symptoms of bladder and rectal compression; 4.People who can determine that myoma is the only cause of infertility or recurrent miscarriage; 5.Fast growing myoma and suspected of malignant change.