Usually, it is not possible for men to take fluconazole once. Fluconazole is primarily used to treat diseases such as cryptococcal meningitis, invasive candidiasis, and chronic atrophic oral candidiasis in adult patients who do not respond well to oral hygiene or topical therapy. It is also used to prevent Candida infections in immunocompromised patients and to prevent recurrence of cryptococcal meningitis in pediatric patients at high risk for recurrence. Fluconazole taken once, does not achieve the effectiveness of the drug, mold will not be immediately eliminated, often need to follow a course of treatment to take the drug, mold can be completely killed. Therefore, it is not possible for men to take fluconazole once. Adverse reactions such as headache, abdominal pain, diarrhea, nausea, vomiting may occur after using this drug, and it is recommended to stop the drug in time and seek medical attention. Patients who are allergic to fluconazole and its inactive ingredients or other azoles and other drugs need to be disabled. In addition, it is recommended that male patients use fluconazole under the supervision of a doctor and not privately.