The first thing to do is to find out the cause of the bitterness in the mouth, the common causes are: 1. acute and chronic hepatitis, cholecystitis, oral administration of six flavors of five spirit tablets, anti-inflammatory and bile tablets, etc. 2. wind and fever cold, oral administration of Pudilan anti-inflammatory oral liquid, Niuhuang detoxification pill, etc. 3. liver and gallbladder damp-heat evidence, bitter and sticky mouth, oral administration of gentian diarrhea liver pill, Danjiao Yiyao pill. 4. spleen and stomach damp-heat evidence, do not think about eating, bitter mouth, epigastric distension, oral administration of Ganlu sterilization pill, Qing stomach. 5, 5. Various tumors with bitter and tasteless mouth need symptomatic treatment.