How many years can one live after pancreatectomy cannot be generalized, it usually needs to be judged according to the primary disease, benign lesions usually do not affect the patient’s life expectancy, malignant lesions are related to the degree of deterioration of the lesion and the treatment. If the patient has benign pancreatic lesions, insulin and pancreatic enzyme secretion may be insufficient after surgical resection, and exogenous insulin and glucagon can be supplemented after pancreatectomy, or even transplantation of pancreatic islets. The patient’s immunity decreases after the operation, and he should pay attention to more rest and actively strengthen the nutrition, which generally will not affect the patient’s life expectancy. If the patient is a malignant lesion of the pancreas, the impact on the patient’s life expectancy varies due to the degree of malignancy and treatment. After pancreatectomy, the cancer cells may recur and metastasize thus affecting the prognosis. Some patients can live for 1-2 years after the operation, while some can survive for more than 10 years, and the 5-year survival rate of pancreatic cancer is generally low, about only 5%. After pancreas resection surgery, it is necessary to develop good living habits, appropriate physical exercise to enhance physical fitness, pay attention to regular diet and regular review, which can effectively prolong life.