The causes of hypospadias in babies are mainly related to genetic factors, endocrine factors, embryological factors, etc. Pregnant women are advised to do a good job of pregnancy checkups and take preventive measures against the risk factors. 1. Genetic factors: people who have had this disease in their immediate family are more likely to develop it, i.e. there is a certain family tendency for the development of hypospadias. 2. Endocrine factors: insufficient secretion of dihydrotestosterone in the body can also lead to hypospadias, which is related to nutritional deficiencies during pregnancy, exposure to heavy metals or radiation, and so on. 3. Embryological factors: the ninth to twelfth week of pregnancy is the critical period for the formation of the fetal penis, during which estrogen can promote the occurrence and development of the urethra and prepuce, and if the secretion of gonadotropins is insufficient at this time, it will lead to developmental abnormality and hypospadias. It is recommended to avoid exposure to heavy metals, radiation and other risk factors during pregnancy; do a good job of prenatal checkups, genetics tests, etc.; pay attention to the observation of the child’s condition, if there is a tendency to wet their pants, urination abnormalities, the need for timely medical treatment.