Pain after pleural effusion aspiration may be due to inflammation, which can be treated with anti-infection therapy and pain relief. 1. Anti-infective treatment: such as clindamycin and roxithromycin. (1) Clindamycin: It is contraindicated in patients with a history of allergy to clindamycin and lincomycin. Adverse reactions include nausea, vomiting, abdominal pain, diarrhea and other symptoms. (2) Roxithromycin: contraindicated in patients with allergy to roxithromycin or other macrolides. The main adverse reactions are abdominal pain, diarrhea, nausea, vomiting and other gastrointestinal reactions. 2. Analgesic treatment: such as ibuprofen extended-release tablets, tramadol extended-release tablets and so on. (1) Ibuprofen extended-release tablets: prohibited for pregnant and lactating women. A few patients may have nausea, vomiting, heartburn and other adverse reactions. (2) Tramadol Extended-Release Tablets: prohibited for sensitive persons. A few patients may experience adverse reactions such as hypotension and tachycardia. The medication must be performed in accordance with the doctor’s advice and carefully read the instructions. Pleural effusion pumping pain may also be the emergence of hemopneumothorax, the likelihood of the emergence of a small, after the above drug treatment did not improve, need to pay attention to the emergence of hemopneumothorax, and timely treatment.