Since pancreatic cancer has no specific symptoms in the early stage, it is difficult to make a clear diagnosis in the early stage. Therefore, 85% of patients are diagnosed when the cancer has invaded the surrounding large blood vessels or organs and cannot be removed. Therefore, we should pay high attention to the high-risk group of pancreatic cancer. The concept of high-risk group of pancreatic cancer is as follows: 1. Those who are older than 40 years old and have no obvious cause of upper abdominal fullness, abdominal pain and weight loss. 2. Those who have a family history of pancreatic cancer. 3.Patients with sudden onset of diabetes, especially atypical diabetes, age over 60 years, lack of family history, no obesity and soon become insulin resistant. 40% of pancreatic cancer patients have diabetes at the time of diagnosis. 4, Patients with chronic pancreatitis, chronic pancreatitis is an important precancerous lesion in a small percentage of patients, especially chronic familial pancreatitis and chronic calcific pancreatitis. 5, mucinous papillary tumors in the pancreatic ducts are also precancerous lesions. 6.Benign lesions with distal gastrectomy, especially those who are more than 20 years postoperative. 7. High risk factors for pancreatic cancer include smoking, heavy alcohol consumption, and long-term exposure to harmful chemicals. The above-mentioned conditions belong to the high risk group for pancreatic cancer and should be taken seriously. If necessary, abdominal ultrasound and CA199 test of peripheral blood should be performed. If pancreatic abnormalities are found, further pancreatic thin scan plus enhanced CT examination should be performed to clarify the diagnosis as early as possible and strive for surgical resection for the purpose of cure.