A little high globulin is not very serious, but it needs to be reviewed periodically to dynamically observe changes in the amount of globulin. Globulin, or immunoglobulin, is an important part of the body’s immune defense system. Globulin may be physiologically elevated and can return to normal on its own; it can also be seen in patients with inflammation, where the immunoglobulin reactively rises to play its anti-inflammatory role, and can return to normal after the inflammation is controlled. Therefore, the above causes of high globulin is not very serious. Malignant plasma cell diseases, such as multiple myeloma and Hutchinson’s macroglobulinemia, may also have high globulin in the early stage of the disease, but with the progress of the disease, globulin will gradually increase, and these patients need early diagnosis and treatment. It is recommended that the patient should consult the hematology department in time, complete the relevant examinations to clarify the cause of the high globulin, and then treat the cause of the disease.