Blisters around the mouth may be caused by herpes simplex, eczema, contact dermatitis and other diseases, and it is recommended that the patient be improved by oral medication and topical medication under the guidance of the doctor. 1. Herpes simplex: Herpes simplex is usually caused by infection with the herpes simplex virus. Patients can take oral antiviral medications such as acyclovir and valacyclovir under the guidance of a doctor. 2. Eczema: blisters around the mouth can also be caused by eczema, patients can use mometasone furoate ointment to improve. 3. Contact dermatitis: dermatitis may be caused by contact with allergic substances, patients can take oral antihistamines, such as levocetirizine hydrochloride, olopatadine hydrochloride. For patients with blisters around the mouth, it is recommended to go to a regular hospital in time for examination, standardized treatment under the guidance of a professional doctor, and not blindly use their own medication.