The cranium plays a very important role in the life functioning of the whole body and the health of the human body. However, cranial defect is a common craniofacial disorder, so cranial bone repair should be carried out in time. Cranial defects can cause great damage to the human body and seriously endanger life and health. First of all, the lack of skull bone will have a greater impact on the skull shape, very unattractive; in addition, the lack of hard skull protection, the brain is easy to be hurt by the outside world, very unsafe; there is a large range of cranial defects, patients due to atmospheric pressure to local scalp sinking, may lead to intracranial pressure imbalance, brain tissue displacement and cerebral hemisphere blood flow reduction and cerebrospinal fluid circulation disorders, thus causing a series of clinical manifestations, mainly including: headache, vertigo, irritability, epilepsy, discomfort with no other explanation, and various mental disorders. After craniosynostosis, patients are also prone to have some low self-esteem, autism and other negative emotions, which are a serious blow to patients psychologically and mentally. It is thus clear that skull repair surgery should be performed promptly after the occurrence of cranial defects. The current materials used to repair the skull are titanium mesh material and PEEK material. However, titanium mesh materials may still have some problems in use, such as postoperative rejection, infection, abrasion of the scalp, material exposure, postoperative cold and heat sensitivity, and interference with CT MRI, among other problems. PEEK is a very good material for cranial repair, with excellent performance, which overcomes the above problems of titanium mesh material and is favored by neurosurgeons and patients with cranial defects, becoming a new trend in cranial repair materials.