Alanine aminotransferase, also known as glutamate aminotransferase, is one of the most common and important indicators in clinical tests. Usually, a high alanine aminotransferase is the first indication of liver disease, but it does not exclude other systemic diseases, and even daily life, work and study have an impact on the results of the aminotransferase test. Alanine aminotransferase (ALT) is widely present in human tissues, and when various tissues and organs in the body are active or diseased, the ALT in them is released into the blood, increasing the serum ALT level. For example, high alanine aminotransferase occurs when the liver is inflamed, and its elevation is positively correlated with liver inflammation. In only 1% of hepatocytes with inflammatory necrosis, serum alanine aminotransferase levels are more than doubled. Therefore, alanine aminotransferase is the most sensitive indicator in the diagnosis of liver lesions. Common diseases that cause high alanine aminotransferase include: hepatitis B, hepatitis C, fatty liver, alcoholic liver, cirrhosis, liver cancer, etc. However, not only diseases can cause abnormal transaminases, but also some other causes of high alanine aminotransferase that are easily overlooked, such as exercise, diet, exertion, alcohol consumption and medication. These non-disease factors are often mistaken for liver disease later on, resulting in over-treatment. What are the causes of high alanine aminotransferase? 1. Exclude high alanine aminotransferase caused by pregnancy, strenuous exercise, medication, alcoholism, etc. If the alanine aminotransferase is high, you should take rest, stop using drugs and alcohol, and then check the alanine aminotransfer after a week, if it is not elevated, you can exclude the disease, otherwise it means that you are infected with some disease. 2, high alanine aminotransferase can also indicate many diseases, such as infectious hepatitis, liver severe disease, active cirrhosis, toxic hepatitis, drug-induced hepatitis, fatty liver, obstructive jaundice, can indicate high alanine aminotransferase. Therefore, elevated alanine aminotransferase (ALT) should be determined based on relevant tests, combined with medical history, symptoms, signs and so on, to find out which disease is causing high alanine aminotransferase. 3, after finding out the disease, you need to be cautious and go to the appropriate regular hospital to receive treatment. When hepatitis B patients have elevated alanine aminotransferase to more than two times the upper limit of the normal value, they should undergo antiviral treatment. The higher the transaminase level, the more active the immune function in the patient’s body, and the better the effect of antiviral treatment. How to identify the causes of high alanine aminotransferase? 1. Alanine aminotransferase itself is very sensitive, and an abnormal list of transaminases does not necessarily mean that something is wrong with the liver. Therefore, for a healthy person, an abnormal liver function test once in a while cannot be used as a basis for the diagnosis of liver disease. 2, in clinical work, doctors refer to the patient’s past medical history, family history and related test results, and finally comprehensive analysis can give a diagnosis of whether the disease and the cause of the disease, sometimes even need to combine a number of indicators to confirm the diagnosis of what disease. The diagnosis of hepatitis B is not difficult, but the difficulty lies in the judgment of the stage of hepatitis B and the development of treatment strategies. The degree of high alanine aminotransferase, HBVDNA results, liver ultrasound and other results, combined with medical history and symptoms are some of the key factors to determine the stage of hepatitis B.