Q: How does gallbladder cancer metastasize? A: Gallbladder cancer is a disease with very high chances of recurrence and metastasis, and there are three ways of metastasis: hematogenous metastasis: the cancer cells are transferred to other organs through blood, the most common one is intrahepatic hematogenous metastasis (because the gallbladder itself is attached to the liver, and it is very likely to be transferred to the liver through blood). Lymphatic metastasis: cancer cells metastasize through corresponding lymph nodes, the most common ones are lymph node metastasis in hilar area and retroperitoneum. Plantation metastasis: after the cancer cells protrude beyond the plasma membrane of the gallbladder, they fall off like seeds and fall into the abdominal cavity, resulting in abdominal plantation metastasis. Direct invasion of surrounding organs: as the tumor grows bigger and bigger, it may also invade adjacent organs, such as liver, stomach, duodenum or colon. Doctor’s tip: patients with acute and chronic cholecystitis and gallbladder polyps should pay attention to timely treatment, and patients with gallbladder stones should also insist on regular review, in order to detect the problem early, and timely symptomatic treatment.