Thyroglobulin low mostly due to drugs, diet and other physiological factors, may also be due to thyroidectomy factors, physiological factors generally do not cause excessive harm to the body, thyroidectomy will lead to hypothyroidism, it is recommended to seek medical attention in a timely manner. 1. Physiological factors: If you are taking exogenous thyroid hormone medication for treatment, you may experience a decrease in thyroglobulin, which generally does not cause too much harm to the body, and will mostly return to normal on its own after the removal of triggers. 2. Thyroidectomy: If the patient has the thyroid gland removed because of thyroid cancer, resulting in low thyroglobulin. After the thyroid gland is removed, it will lead to insufficient secretion of thyroid hormone in the body, which will lead to hypothyroidism and decrease in metabolic rate. Patients with low thyroglobulin are advised to be admitted to the hospital for examination under the supervision of a doctor to find out the exact cause after physiological factors have been ruled out.