Strictly speaking, anti-inflammatory drugs in medicine refers to non-steroidal anti-inflammatory drugs and hormones, but people also often consider antibiotics as a kind of anti-inflammatory drugs. If you have a cold with high fever, you can take acetaminophen and other antipyretics; if you have a bacterial infection, you will need to take cephalosporin and other anti-infective treatments; if you have a cold caused by a simple viral infection, you do not need to take anti-inflammatory drugs. 1. Fever: If you have a fever and your temperature exceeds 38.5 degrees, you can take acetaminophen or ibuprofen to reduce the fever. 2. Bacterial infection: If a cold is combined with or secondary to a bacterial infection, accompanied by yellow nasal discharge, coughing up yellow sputum and other manifestations, you need to follow the doctor’s instructions to use antibiotics for treatment, such as cefuroxime, cefaclor, amoxicillin and so on. 3. Viral infections: If the cold is only purely viral, it can be treated symptomatically with conventional anti-cold medications, such as aminoglutethimide capsules, compound aminophenol alkylamine tablets, and antiviral medications such as oseltamivir can be taken by immunocompromised people or patients with influenza. There is no bacterial infection, no high fever, no need to use antibiotics and other anti-inflammatory drugs treatment. During the cold, patients should pay attention to more rest and eat a light diet. In serious cases, it is recommended to go to the hospital for examination and treatment so as not to delay the condition.