The treatment of acute ischemic stroke usually includes intravenous thrombolysis, arterial thrombolysis, anticoagulation and antiplatelet therapy, and emergency endovascular therapy. Among these, endovascular interventions can improve revascularization, but clinical trials of endovascular thrombectomy have been found to produce varying prognostic outcomes; and the effectiveness of endovascular thrombectomy in different populations needs to be better defined. To investigate the association between endovascular mechanical thrombectomy and clinical outcome in patients with acute stroke, the investigators conducted a meta-analysis study. The eligible clinical trials included in the meta-analysis were all endovascular thrombectomy trials with standard treatment as a control and intravenous thrombolysis with intravenous tissue-type fibrinogen activator injection. Investigators assessed risk ratios and 95% confidence intervals for all clinical regressions and took subgroup analyses and sensitivity analyses to examine whether patients’ functional recovery was related to a specific imaging diagnosis, treatment, or the nature of their clinical trial. Various regression indicators were scored using a modified Rankin scale. All data included 2423 patients from eight clinical trials with a mean age of 67.4 years and a positive or negative age difference of 14.4 years, of whom 1131 were women. 1313 of the 2423 patients underwent endovascular thrombectomy and 1110 received standard treatment with tPA intravenous thrombolysis. The results of the data analysis were as follows: Scale scores showed that endovascular thrombectomy had a significant associated treatment benefit. comparison of patients’ functional independence within 90 days: endovascular thrombectomy restored functional independence 557/1293, or 44.6%; standard treatment restored functional independence 351/1094, or 31.8%. The incidence of symptomatic intracranial hemorrhage within 90 days: 70 cases (5.7%) with endovascular thrombectomy and 53 cases (5.1%) with standard treatment. all-cause mortality within 90 days: 218 cases (15.8%) with endovascular thrombectomy and 201 cases (17.8%) with standard treatment. All-cause mortality within 90 days: endovascular thrombectomy occurred in 218 cases (15.8%); standard treatment in 201 cases (17.8%). In patients with acute ischemic stroke, endovascular thrombectomy was associated with better functional recovery and a higher rate of angiographic detection of revascularization than standard treatment with tPA intravenous thrombolysis. However, there was no significant difference in the incidence of symptomatic intracranial hemorrhage and all-cause mortality within 90 days in patients.