Numbness of the middle finger and index finger is considered to be related to localized pressure, cervical spondylosis, cerebral infarction, multiple peripheral neuritis, carpal tunnel syndrome, and so on. 1. Localized pressure: when the middle finger and index finger are compressed by pressure, numbness may occur due to insufficient local blood oxygen. 2. Cervical spondylosis: the disease is related to cervical degenerative changes, cervical spine developmental spinal stenosis, chronic strain and so on. Common symptoms include neck and back pain, numbness and weakness of limbs, nausea and vomiting, blurred vision, etc., and numbness of middle finger and index finger. 3. Cerebral infarction: mainly related to atherosclerosis of large arteries and occlusion of small arteries. Typical symptoms include paroxysmal sensory impairment, motor dysfunction, dizziness, blackout, hemiparesis, aphasia, ataxia, etc., which may be manifested as numbness of the middle finger and index finger. 4. Multiple peripheral neuritis: the disease is related to drugs, exposure to chemicals, alcoholism and so on. Typical symptoms of patients include sensory disorder, motor disorder, autonomic disorder, etc., which can also be manifested as numbness of the middle finger and index finger. 5. Carpal tunnel syndrome: the disease can also cause numbness of the middle finger and index finger in some patients. Carpal tunnel syndrome is related to exogenous compression, small cavity of carpal tunnel, etc. Common symptoms include abnormal sensation of hand and wrist, weakness of holding objects, decreased muscle strength, etc. It causes numbness of middle finger and index finger. There are many causes of numbness in the middle and index fingers, such as diabetic peripheral neuropathy, cerebral hemorrhage, etc. It is recommended that patients seek timely medical treatment.