Acute pyelonephritis and glomerulonephritis are different in pathogenesis, clinical manifestations and treatment. 1. Pathogenesis: Acute pyelonephritis is a common urological disease caused by various pathogenic microorganisms invading the renal pelvis and renal parenchyma; glomerulonephritis refers to a group of diseases caused by a variety of reasons, such as infection, metabolism, autoimmune abnormalities and so on. 2. Clinical manifestations: Acute pyelonephritis is most common in the reproductive age group, the elderly and the immunocompromised group. Patients usually have chills, high fever, pain in kidney area, etc. Glomerulonephritis takes proteinuria, hematuria, hypertension, edema as the basic clinical manifestations, which may be accompanied by different degrees of renal function decline, and the condition may develop into chronic renal failure if the disease is prolonged. 3. Treatment: Acute pyelonephritis is mainly treated with anti-infective therapy, and amoxicillin and cefuroxime can be chosen as the treatment drugs; the treatment of glomerulonephritis is not the same, and suitable treatment programs are chosen according to the specific causes of the disease, such as anti-infective, antihypertensive, glucose lowering, immunosuppression and so on. Patients with any discomfort, it is recommended to promptly to the regular hospital, follow the doctor’s instructions standardized treatment, the above medication should follow the doctor’s instructions, not unauthorized use, so as not to aggravate the condition.