Anti-cyclic citrullinated peptide antibody less than 7 U/mL is usually normal. Due to the different test standards of each hospital, the actual test report shall prevail, and it is recommended to interpret the test under the guidance of a doctor. Anti-cyclic citrullinated peptide antibody is mainly used to diagnose rheumatoid arthritis in clinic, especially it can be used to diagnose early rheumatoid arthritis. It has high sensitivity and specificity for rheumatoid arthritis and is a highly specific indicator for its early diagnosis. However, the diagnosis of rheumatoid arthritis in the clinic should also be analyzed and judged comprehensively, and it is necessary to assess the patient’s clinical symptoms to see whether there is symmetric swelling and pain in the joints, morning stiffness, etc., and at the same time, it is necessary to combine with the antinuclear antibody spectrum, rheumatoid factor, C-reactive protein, blood sedimentation, etc., to carry out the diagnosis. If the anti-cyclic citrullinated peptide antibody is found to be higher than normal, it is recommended to consult the rheumatology and immunology department of a regular hospital in a timely manner and follow the doctor’s instructions for standardized diagnosis and treatment.