Gastric bloating during H. pylori treatment is not normal, but there is no need to be particularly worried; this symptom may be an adverse drug reaction and usually recovers after stopping the medication. H. pylori treatment is now commonly treated with drug quadruple therapy, such as amoxicillin, clarithromycin combined with omeprazole, bismuth aluminate compound regimen. As antibiotics and proton pump inhibitors such as omeprazole may cause gastrointestinal flora imbalance as well as a decrease in gastric acid secretion, they may lead to dyspepsia, gastrointestinal and other adverse reactions. The occurrence of gastric distension and other discomforts is usually not a cause for special concern, and such adverse reactions may disappear at the end of treatment. If symptoms persist, intervention can be made with gastric motility medications such as domperidone and medications to regulate intestinal flora such as Bifidobacterium bifidum. Prompt hospitalization is recommended in the presence of H. pylori infection. The above drugs need to be used under the guidance of clinicians, and unauthorized use of drugs is prohibited.