If you wake up in the middle of the night with dry mouth and bitterness, it depends on whether it is a short-term, single episode, or a long-term episode, which is essentially different. If the symptoms appear for a long time, you need to consider whether there are related pathological factors, such as abnormal oral infection, gingivitis, periodontitis, tongue inflammation, pharyngitis, oral ulcer, or gastritis, gastric ulcer, poor digestion, and gallbladder disease, bile reflux, etc. Therefore, if this symptom appears for a long time, you need to conduct the appropriate examination to clarify the cause. If you wake up in the middle of the night with dry mouth and bitter mouth for a short period of time or for a single time, consider whether there are bad eating and living habits in the near future, such as eating too much at night, stress, lack of sleep or too much use of cell phones and computers. To actively improve these aspects, eat more fresh vegetables and fruits, drink more water, and observe whether the symptoms improve. There are many reasons for waking up in the middle of the night with dry mouth and bitter mouth, so further examination is needed to give appropriate treatment, and then the next examination and treatment will be decided according to the degree of relief of dry mouth and bitter mouth symptoms.