Atherosclerotic occlusive disease of the lower extremities, refers to the formation of atherosclerotic plaques in the lower extremity arteries, causing narrowing and occlusion of the lower extremity arteries, which in turn leads to chronic ischemia of the limbs. The onset of the disease is related to endothelial damage, membrane lipid metabolism disorders, and changes in arterial hemodynamics. Clinical manifestations include localized coldness of the affected limb, numbness, intermittent claudication, ischemic ulcers of the limb, gangrene, etc. Clinical treatment is mainly based on medication and surgery. 1. Pharmacological treatment: It is often necessary to take aspirin, clopidogrel and other drugs to inhibit platelet aggregation as prescribed by the doctor; take statin drugs to treat atherosclerosis through competitive inhibition of endogenous cholesterol synthesis rate-limiting enzyme, HMG-CoA reductase, and block intracellular hydroxymethylglutaric acid metabolic pathway, so as to reduce intracellular cholesterol synthesis. Such as atorvastatin, simvastatin and so on. 2. Surgical treatment: Clinical doctors will choose the appropriate surgical treatment method according to the actual condition of the patient. Commonly used surgical procedures include: percutaneous transluminal angioplasty (PTA) combined with stenting, endarterectomy, arterial bypass, amputation and so on. If patients are diagnosed with arterial ulcers of the lower limbs, they should go to the hospital in time to avoid delays.