Cervical immunohistochemistry results of P16 positivity and Ki-67 negativity are usually indicative of low-grade squamous intraepithelial lesions of the cervix. Cervical immunohistochemistry of P16 and Ki-67 antibodies can help identify low-grade squamous intraepithelial cervical lesions and high-grade squamous intraepithelial cervical lesions. 1. P16 is an anti-oncogene that is directly involved in the regulation of the cell cycle. If it is regulated abnormally and appears positive, it may lead to malignant cell proliferation, resulting in the development of malignant tumors. 2. Ki-16 is an associated antigen of proliferating cells, which is closely related to mitosis, and is mainly used to mark cells in the proliferation cycle in the clinic. If it appears positive, it indicates that the tumor cells have active growth and poor tissue differentiation ability. Therefore, immunohistochemistry results show positive P16 and negative Ki-67, indicating that the cell activity is not high, mostly suggesting low-grade squamous intraepithelial lesions of the cervix. If you have any uncomfortable symptoms, you need to go to the hospital as soon as possible, and the doctor will formulate an individualized diagnosis and treatment plan according to your specific condition, so as to avoid delaying your condition.