Patients with interstitial pneumonia may not always be able to get the New Crown vaccine while on hormones, depending on their condition, and should not be vaccinated during an exacerbation. Patients with interstitial pneumonia can be vaccinated with the new crown vaccine if their condition is stabilized, but it is not recommended if they have an acute exacerbation of the disease. Although hormonal drugs are not a contraindication for vaccination, this drug is usually used for some serious diseases or acute exacerbation of diseases, during the period of taking the drug, it may lead to a decline in the body’s immunity, but also prone to endocrine disorders, which will affect the effect of the vaccination of the new crown vaccine. When patients suffering from interstitial pneumonia are taking hormonal drugs, it is recommended to go to the hospital for consultation, under the comprehensive advice of the doctor to decide whether it is possible to vaccinate with the new crown vaccine, do not privately vaccination, so as not to aggravate the condition caused by adverse reactions.