Creutzfeldt-Jakob disease is an infectious disease that attacks the central nervous system and is not hereditary. Creutzfeldt-Jakob disease is a disease caused by infectious prions, which are very stable, resistant to heat, ultraviolet light, and resistant to chemicals, and even sterilization, freezing, and drying cannot kill them. Prions do not have a genetic component, so the disease is not inherited. Currently the main factors for the transmission of Creutzfeldt-Jakob disease are close contact transmission and medical transmission. The disease is transmitted through the patient’s body fluids, blood, and medical and surgical instruments, including the patient’s central nervous system tissues, tonsils, and spleen, which are infectious. Although Creutzfeldt-Jakob disease is not hereditary, family members must take protective and isolation measures when coming into contact with a person with Creutzfeldt-Jakob disease to avoid infection during contact.