Most patients with gallstones have no obvious symptoms and are usually detected through routine physical examination. Some patients with acute attacks may have abdominal pain, indigestion, nausea, vomiting and other symptoms, or even high fever, chills and jaundice. Depending on the location of the stones, the symptoms of gallstones are also different.1. Gallbladder stones: Most gallbladder stones can be asymptomatic, but some patients may show vague pain in the upper abdomen, sometimes accompanied by acid reflux and discomfort of fullness. This pain often appears after a full meal, or after eating oily and fatty foods. Severe cases will have biliary colic, mainly due to gallbladder spasm, which is typically manifested as severe paroxysmal pain in the right upper abdomen, and the pain can radiate to the right side of the shoulder and back; 2. In severe cases, acute biliary obstruction may lead to sepsis, shock and even neuropsychiatric abnormalities. 3. Intrahepatic bile duct stones: The clinical manifestations vary according to the course and pathology of the disease, from stones confined to a certain section of the intrahepatic bile duct with no obvious clinical symptoms in the early stage to stones in the later stages of the bile duct system inside and outside the liver, even complicated by biliary cirrhosis, liver atrophy and liver abscess. Therefore, the clinical manifestations are very complicated, which can be manifested as epigastric pain, chills, fever, jaundice, asymmetric enlargement of the liver and pressure pain, etc.