With advances in clinical immunology research, treatment of the vast majority of patients with lupus erythematosus has been able to achieve complete clinical remission. At this time, the comprehensive needs of patients’ lives and livelihoods have been met and enhanced in many ways. The research topic of “Pregnancy and fertility in lupus erythematosus patients with prognosis” and the study on maternal and infant follow-up of lupus erythematosus, which has been our consistent research content for more than 20 years, provides the following references for many female patients of childbearing age with fertility desire: 1. Lupus erythematosus is not an incurable disease, but only an autoimmune disease. 2. Systematic and standardized treatment can achieve complete clinical remission for most patients in the early and middle stages. 3. Fertility is not undesirable. 4. The prerequisite for conception is that the lupus erythematosus disease has reached the SLEDAI remission standard for more than six months. 5. The simultaneous requirement is at low doses of hormones and non-contraindicated immunosuppressive agents for pregnancy. 6. The patient’s physical underlying conditions, such as age, previous history of conception, and whether there has been lupus nephritis or thrombocytopenia and other vital organs, are also assessed. 7. Choose the conception method according to their conditions, such as natural or assisted conception. 8.Preparation for enhanced treatment for changes in condition during pregnancy. 9. Thoughtful preparation for possible serious fetal conditions. 10. Timing and mode of delivery in late pregnancy, cesarean section or natural delivery. Because of the joint influence of maternal and fetal condition. 11.Anti-SSA antibody positive pregnant women’s understanding of the low chance of fetal inheritance. 12, Breastfeeding is allowed, but only when the mother does not produce and has minimal effect on the infant in the presence of small doses of hormones and non-contraindicated immunosuppressive therapy. 13. The entire pregnancy should be guided and tested jointly by a rheumatologist and an obstetrician-gynecologist.