Pregnant women with a previous history of recurrent genital herpes and those who acquired infection in the first half of pregnancy have a low risk of HSV transmission to the newborn (1%); in contrast, pregnant women with genital herpes infection near the time of delivery have a high risk of HSV transmission to the newborn (30%-50%). In addition, HSV culture at the time of pregnancy does not predict detoxification at the time of delivery. Therefore, the key to preventing neonatal herpes is to prevent the acquisition of genital HSV infection in pregnant women during the second trimester. For susceptible pregnant women, unprotected genital and oral sexual contact with a sexual partner with HSV infection or suspected infection should be avoided during pregnancy. Because of the high likelihood of neonatal herpes in newborns born to HSV-infected pregnant women during the second trimester, especially during the first 6 weeks of labor, it is recommended to consider cesarean delivery as well as acyclovir prophylaxis. The method is: acyclovir 20 mg/kg daily by intravenous drip for 10-21 days. The use of drugs such as acyclovir in pregnant women is controversial and, if used, the pros and cons should be weighed and the patient’s informed consent obtained. It is currently advocated that pregnant women with a first episode of genital herpes may be treated with oral acyclovir. In pregnant patients with frequent recurrent or recent genital herpes infections, continued acyclovir treatment during the last 4 weeks of pregnancy may be used to reduce the appearance of active damage and thus reduce the rate of cesarean delivery. Acyclovir therapy may be dispensed in pregnant women with a history of recurrent genital herpes but without any signs of recurrence in the last full term. In pregnant women with active lesions or prodromal symptoms, cesarean section may be performed before rupture of membranes, provided there are no contraindications, but cesarean section does not completely prevent the development of herpes in the newborn. For pregnant patients without active lesions, vaginal delivery is possible, but their newborns should be monitored closely after delivery for fever, lethargy, weak sucking during breastfeeding, convulsions, or occurrence of skin lesions for timely management.