About 16% malignant naïve myeloid cells consider the possibility of leukemia, it is recommended to further improve the chromosome, gene and other tests, in order to clarify the diagnosis and timely treatment. Malignant naïve myeloid cells are what we call leukemia cells, and the proportion of naïve cells in the bone marrow of a normal person should be less than 5%. If about 16% of malignant naïve myeloid cells are found in the bone marrow examination, it indicates that they are undergoing a large amount of proliferation, and the possibility of leukemia is high. Therefore, it is necessary to further improve the chromosome, gene and other related examinations, to clarify the type and typing of the disease, and to formulate the appropriate treatment plan (chemotherapy, targeted therapy, etc.). If the bone marrow examination shows about 16% malignant naïve myeloid cells, the patient should consult the doctor immediately to clarify the diagnosis and follow the doctor’s instructions to avoid delay of the disease.