The successful treatment of burn patients is often predicated on the complete coverage of wounds, and burn surgeons may often need to think about the coverage of wounds, and it can even be said that burn surgeons have been dealing with all kinds of wounds all their lives. In the process of clinical treatment, a variety of wounds are often encountered. The author believes that the treatment effect of the following types of wounds is often not very exact, and some are even more difficult to treat, so the patient should be informed of the difficulty of treatment during the initial consultation or preoperative conversation, and the patient’s understanding should be fully obtained to avoid unnecessary misunderstandings. 1, a variety of radiation-treated wounds, even if the irradiation has been a long time, or the irradiation range is limited, the amount of irradiation is also very small (such as gamma knife) wounds. The author has dealt with dozens of patients with sacrococcygeal tumor resection and radiation treatment incisions that do not heal or have painful local scar growth or repeated ulceration, most patients experience a slow necrotic liquefaction process, and generally perform skin flap or skin graft surgery in the timing and procedure should be carefully considered. 2.Wounds formed by various vascular diseases, such as varicose veins and arteriovenous fistulas, are often in the distal part of the lower limbs, and even if the patients are young, they often bleed a lot and scarify during surgery, and the survival rate of skin grafting may be very low if the conditions are not well mastered. 3.Wound formed after resection of tumor on the body surface, such as the wound formed after extensive inguinal lymph node dissection for penile cancer, often has tumor cell residue, which is difficult to be completely closed even if covered with skin flap. 4.The trauma of the extremity of patients with long duration of diabetes and rheumatic immune system diseases. 5, long-term use of hormones, as well as some local incisions for anti-scar purposes the application of the Leprosy and other drugs formed by the non-healing wound. 6, the body surface wound is very small, but the disease is long, there are suspicious under the wound cavity, foreign bodies, necrotic tissue, infection foci.