The main difference between amlodipine benzenesulfonate and fosinopril sodium is that they belong to different kinds of antihypertensive drugs, with some differences in efficacy and adverse effects. 1. Amlodipine besylate is a calcium antagonist, while fosinopril sodium is an angiotensin-converting enzyme inhibitor (ACEI). 2. Therapeutic effect is different, although the above two drugs are antihypertensive drugs, have a certain effect on lowering blood pressure, but fosinopril sodium and other ACEI antihypertensive drugs have a certain inhibition of myocardial remodeling, for patients with cardiac insufficiency to take the product can play a role in the protection of cardiac function, and amlodipine benzenesulfonate has a certain therapeutic effect on angina pectoris. 3. Adverse reactions are different, for example, amlodipine benzenesulfonate can lead to ankle edema and other adverse reactions, fosinopril sodium may lead to patients with cough and other side effects. In addition, amlodipine benzenesulfonate allergy should be prohibited, and fosinopril sodium is contraindicated for fosinopril sodium allergy, pregnant and lactating women, severe renal insufficiency; the above drugs should be used reasonably under the guidance of a doctor, and the adverse effects of the drug need to be monitored during the period of drug use.