Penis inserted into the vaginal opening after the pain that pain in sexual intercourse, caused by pain in sexual intercourse for a number of reasons, generally considered gynecological inflammatory diseases, gynecological tumors, vaginal dryness, coitus exertion and other reasons. 1. Gynecological inflammatory diseases: the most common reason, usually seen in vaginitis, pelvic inflammatory disease and other diseases. It can be manifested as pain during sexual intercourse accompanied by vulvar itching, abnormal leukorrhea, abdominal pain and other manifestations. 2. Gynecological tumor: usually seen in endometrial cancer, cervical cancer and other diseases, which can be manifested as pain during sexual intercourse, accompanied by bleeding during sexual intercourse, anemia, emaciation, abdominal pain and other symptoms and manifestations. 3. Vaginal dryness: generally due to the decrease of estrogen level, mostly seen in middle-aged and old women, due to vaginal dryness caused by friction during sexual intercourse. 4. Excessive coital exertion: if both husband and wife in the sexual life of coital exertion or take some violence and other methods, can damage the vaginal mucosa and lead to pain. Clinical pain in sexual intercourse need to go to the hospital, a clear diagnosis of the cause of targeted treatment, do not unauthorized use of drugs.