After syphilis infection, the patient usually develops the corresponding symptoms in 1-13 weeks. The main symptom of stage I syphilis is hard chancre, which can be seen as round or oval sores on the penis, coronal groove, glans and foreskin in men, and on the labia, labia ties and cervix in women. The symptoms of syphilis rash will appear after the hard chancre disappears. About 80% of people can develop skin and mucous membrane damage, which can include rash, flat warts, baldness and mucous membrane damage. Once a patient enters stage III syphilis, there is usually damage to several organs, mainly the heart and nerves, and the symptoms are usually more severe.