Loose and painful large teeth may be caused by trauma, acute apical periodontitis, combined periodontal-pulp lesions, etc. The main treatments include immobilization, root canal treatment, periodontal system treatment, and extraction. 1. Fixation: If the tooth loosening pain is caused by trauma and the tooth can be retained, fixation and repositioning can be used. 2. Acute apical periodontitis: the acute stage of apical periodontitis of teeth can cause loosening and pain of large teeth, and the main treatment is root canal treatment. 3. Combined periodontal-endodontic lesions cause loosening and pain of the large teeth, in addition to root canal treatment, periodontal system treatment is also needed. 4. Extraction: A tooth that cannot be retained can be extracted. There may be other reasons for the looseness and pain of large teeth, it is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or treatment under the guidance of the doctor.