V. Prevention and control measures (a) Prevention of import 1, pay attention to international epidemic dynamics closely track information on the progress of the international epidemic of Zika virus disease, dynamic risk assessment, to provide the basis for the development and adjustment of local prevention and control strategies and measures. 2, according to the need to issue travel health tips Local health and sanitation departments to assist foreign affairs, business, tourism and entry-exit inspection and quarantine departments to do a good job to travelers to Zika virus disease endemic areas and overseas Chinese citizens publicity and education and health tips. 3, do a good job of port health quarantine Health and quarantine departments once found suspected cases, should promptly notify the health and family planning departments, and jointly do a good job of epidemic investigation and disposal. (B) Case monitoring and management 1. Case monitoring and early detection When patients with fever, rash and muscle and joint pain are found in medical institutions at all levels, attention should be paid to understanding the epidemiological history of the patient (travel history in endemic areas), considering the possibility of the disease, and timely sampling for testing. In addition, the possibility of Zika virus infection should also be considered for mothers with newborns presenting with microcephaly who have a suspicious epidemiological history. 2.Epidemiological investigation Conduct case investigation of relevant cases, focusing on the patient’s activity history 2 weeks before the onset of the disease to identify suspected infection sites and search for the source of infection; also investigate the activity history one week after the onset of the disease and conduct case search to assess the risk of infection and epidemic. 3. Case search For imported cases, travel history should be traced in detail, with emphasis on searching among those who travel with them. If the case has been active in the county (district) from the time of entry to 1 week after the onset of the disease, the suspected case should also be searched in their living and working areas. In the case of local infection epidemic cases, the case residence or a number of households adjacent to it, the case’s workplace and other places of activity as the center, reference Aedes aegypti activity range to delineate the spatial extent within a radius of 200 meters as the core area, an infected person can be delineated multiple core areas, search for cases in the core area. According to different building types in urban or rural areas, Aedes aegypti activity range, appropriate to expand or narrow the search radius. 4, case management for the acute phase of the case must take anti-mosquito isolation measures, anti-mosquito isolation period from the onset of not less than 7 days, and should continue until the fever symptoms subside. Serious cases should be hospitalized. Medical and health personnel in the treatment and epidemiological investigation, should take standard protection. On the basis of good case management and general nosocomial infection control measures, health care institutions should implement anti-mosquito and mosquito control measures to prevent nosocomial transmission. (C) vector monitoring and control There are vector distribution areas, in addition to the above work, but also need to do a good job of vector monitoring and control work. 1, daily monitoring and control Health and family planning administrative departments at all levels are responsible for leading and organizing local disease prevention and control agencies to carry out community-based Aedes mosquito density monitoring, including Aedes species, density, seasonal growth and so on. Daily monitoring scope, methods and frequency requirements as dengue fever, can refer to the “dengue fever vector Aedes aegypti monitoring guide” in the routine monitoring. When the vector Aedes aegypti Brett index and ovitrap index exceeds 20, the local government should be promptly requested to organize a patriotic health campaign to remove indoor and outdoor breeding sites of various vectors of Aedes aegypti and carry out preventive mosquito control campaigns to reduce the density of Aedes aegypti to reduce or eliminate the risk of outbreaks of Zika virus disease and other mosquito-borne diseases. 2, emergency surveillance and control In the Aedes aegypti activity season found imported or local cases of Zika virus disease infection, emergency surveillance should be initiated. Aedes vector emergency surveillance area, methods and frequency requirements with dengue fever, can refer to the “dengue vector Aedes mosquito surveillance guidelines” in the emergency surveillance. When there are cases of Zika virus disease and the epidemic site as the center of a 200-m radius Brett index or ovitrap index ≥ 5, the alert area (core area outreach 200-m radius) ≥ 10, or Brett index or ovitrap index greater than 20, the emergency vector Aedes aegypti control should be initiated. The main points of emergency control of Aedes aegypti include: do a good job of community mobilization, patriotic health campaign, do a good job of mosquito breeding ground cleanup; educate the public to do a good job of personal protection; take a precise emergency adult mosquito kill at the epidemic site, etc., through a comprehensive vector Aedes aegypti prevention and control measures, as soon as possible to control the Brett index or ovitrap index below 5. (iv) Publicity and communication Areas at risk of epidemic should adopt a variety of effective forms to carry out health education activities in an easy-to-understand manner. Publicity points include: Zika virus disease is transmitted by the bite of Aedes aegypti mosquito (commonly known as Aedes aegypti or Aedes aegypti); Aedes aegypti mosquitoes breed in water tanks, water pots, tires, flower pots, vases and other containers of stagnant water; removing stagnant water, turning over pots and pans, and removing mosquito breeding sites can prevent Zika virus disease epidemics; in areas where epidemics occur, wear long-sleeved clothing and pants, apply anti-mosquito water to exposed parts of the body, use mosquito repellent or use mosquito nets and anti-mosquito nets Prevent mosquito bites. In addition to general travel health tips, pregnant women and women planning to become pregnant should be reminded to be cautious when traveling to countries or regions where Zika virus disease is endemic, and to take strict personal protective measures against mosquito bites if they do need to travel to these countries or regions. If they suspect possible Zika virus infection, they should seek prompt medical attention, report their travel history voluntarily, and receive medical follow-up. (E) Training and laboratory capacity building 1. Strengthen training of medical personnel and improve disease identification ability Carry out training of medical personnel on diagnosis and treatment to improve disease diagnosis and identification ability. Key areas should carry out intensive training of grassroots medical personnel on Zika virus disease-related knowledge before the annual epidemic season, in conjunction with the prevention and control of dengue fever and chikungunya fever, to enhance the understanding of Zika virus disease and timely detection and reporting of suspected Zika virus infection cases. 2. Establish Zika virus detection capacity Establish and gradually promote laboratory testing techniques for Zika virus. The provincial centers for disease prevention and control should establish relevant techniques and methods for laboratory testing as soon as possible, make good reserves of laboratory techniques and reagents, and gradually improve the laboratory testing capacity of the grassroots centers for disease prevention and control for the disease to respond to possible outbreaks.