Severe atrophic gastritis is a chronic digestive disease characterized by atrophy of the epithelium and glands of the gastric mucosa, thinning of the gastric mucosa, and thickening of the mucosal base. When patients suffer from Helicobacter pylori infection, overeating, irregular diet, and low immunity can easily lead to atrophic gastritis, which can gradually develop into severe atrophic gastritis without timely medical control. Severe atrophic gastritis often manifests as abdominal discomfort, stomach pain, nausea, vomiting and other symptoms, accompanied by acid reflux, weakness, poor nausea, hiccups, bloating, etc. The differential diagnosis can be made through routine blood, gastric fluid analysis, gastroscopy, pathological examination, etc. After the cause of the disease is clearly identified, the patient can follow the doctor’s prescription for drug treatment, such as colloidal bismuth and aluminum thioglycollate to protect the gastric mucosa, and domperidone and mosapride to promote gastrointestinal peristalsis and prevent reflux to slow down the progress of the disease and promote recovery. It is also necessary to apply “quadruple therapy” to treat H. pylori infection, such as amoxicillin, clarithromycin, omeprazole and bismuth for combined treatment, and review the treatment regularly. In daily life, patients should relax, keep a relaxed mood, regular diet, eat less spicy, greasy, cold and other foods.