Mediastinal lymph node enlargement medication depends on the cause of the disease, the use of antibiotics due to infection, tuberculosis due to the use of anti-tuberculosis drugs, tumor due to the use of chemotherapeutic drugs, the use of drugs in accordance with the doctor’s instructions. 1. If the mediastinal lymph node inflammation is caused by bacterial infection, antibiotics can be used for treatment, generally including penicillin such as penicillin, cephalosporins such as ceftriaxone, quinolones such as ofloxacin and so on. 2. If the mediastinal lymph node enlargement is caused by tuberculosis, anti-tuberculosis drugs are usually chosen, and the first-line anti-tuberculosis drugs include isoniazid, rifampicin, pyrazinamide and so on. 3. Tumor may also cause mediastinal lymph node enlargement, at this time, the main consideration is to take corresponding anti-tumor chemotherapy drugs, such as lung cancer can choose paclitaxel. If you find enlarged mediastinal lymph nodes, you should go to the hospital in time for relevant examination, clarify the cause of the disease, and take active treatment.