A fish-like lung biopsy may be caused by lung adenocarcinoma, synovial sarcoma, cryptococcosis of the lung and other diseases in the body. 1. Lung adenocarcinoma: lung adenocarcinoma is a type of non-small cell carcinoma, which often occurs in women. Pathologically, the tumor is round or oval in shape, and most of them have no envelope but are incomplete. When lung biopsy is performed, the structure is different, some of them are solid mass or small striated arrangement, some of them can be seen glandular cavity formation, and some of them can be fish-like. 2. Synovial sarcoma: when synovial sarcoma invades into the lungs, it will affect the alveoli and the surrounding bronchial tubes, resulting in abnormal respiratory function or circulatory function. It may cause fish-like changes on lung biopsy. 3. Pulmonary cryptococcosis: it is a fungal disease caused by cryptococcal infection in the lungs, which can cause granulomatous lesions in the lesion area, and the specimen can be fish-like in the lung biopsy. When the lung biopsy is abnormal, you need to go to the hospital immediately for a comprehensive examination.