Most thyroid nodules 4b can be cured after surgery, and it is recommended that patients who find nodules seek prompt medical attention. Thyroid nodules are categorized according to the TI-RADS grading from 1 to 6, where grade 4 refers to thyroid nodules suspected to be malignant, which can be further subdivided into 3 categories, 4a, 4b, and 4c. 4b is moderately suspected to be malignant, with a malignancy rate of 10%~50%. When malignancy occurs, patients are advised to undergo ultrasound-guided fine-needle aspiration biopsy to clarify the nature of the nodule in order to determine the next step in the treatment plan. (1) If the nodule is benign, it can usually be cured by surgical resection, or if the patient does not wish to undergo surgery, it can be observed conservatively with regular checkups. (2) If the nodule is malignant, but the nodule is well staged and at an early stage, without distant metastasis or lymph node metastasis, it may be clinically cured through comprehensive treatment, such as surgical treatment (thyroid lobectomy, subtotal thyroidectomy, etc.), medication (e.g., thyroid tablets, levothyroxine sodium tablets, etc.), chemotherapy, and radiation therapy. (3) If the nodule is malignant and poorly staged, and progresses to the middle or late stage, it may be incurable. Thyroid 4b should be evaluated under the guidance of a doctor as early as possible according to the specific circumstances and then given a standardized treatment plan, in order to strive for a good prognosis.