Soft tissue sarcoma, if belongs to malignant tumor, usually manifests as local swelling, lump, pain, and limited movement of the lump. For such patients, all preoperative examinations should be actively conducted to exclude contraindications to surgery, and then surgical resection should be scheduled as early as possible. In the process of surgery, it is necessary to carry out peripheral extended resection to reduce the subsequent recurrence, and the specimen after resection needs to be sent for pathological examination, according to the type of examination, to determine the subsequent radiotherapy and chemotherapy, to minimize the recurrence rate of sarcoma. The degree of malignancy of sarcoma is very high, once recurrence or metastasis, it will jeopardize the patient’s life, so it should be taken seriously, once found, it needs to be diagnosed and treated early.