Children’s fever has been shouting stomach pain can be seen in the digestive tract disease or other systemic febrile diseases, the treatment needs to be based on the cause, such as acute appendicitis need to fight infection, if necessary, need to perform surgical treatment. 1. Digestive tract diseases: (1) Acute gastroenteritis: fever, abdominal pain or vomiting, etc. For this kind of children’s treatment, we need to pay attention to the reasonable diet, pay attention to the balance of water and electrolytes, timely hydration to avoid dehydration. If there is bacterial infection, antibacterial drugs such as cefaclor should be used for anti-infection treatment. (2) Acute appendicitis: a common gastrointestinal surgical disease, clinical fever, abdominal pain symptoms, abdominal pain can show progressive aggravation, for this kind of children need to actively use antibacterial drugs, such as cefuroxime anti-infective treatment, if necessary, need to be evaluated by specialists for surgical treatment. 2. Other systemic febrile diseases: such as acute upper respiratory tract infections, clinical recurrence of fever, and affect the gastrointestinal function, abdominal pain can occur. Need to actively treat the original disease, viral infection is generally supportive treatment, bacterial infection requires the use of sensitive antibiotics, such as cefixime. Children with fever, abdominal pain symptoms need to consult a doctor in a timely manner, after a clear diagnosis for targeted treatment. All of the above drugs should be used under the guidance of a physician.